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Hi Tatiana, I know it is SO hard for parents to trust and accept that fevers are okay, even if really high

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Recent studies have identified that the mitochondrial AAA protease Lon interacts with multiple protein partners to promote the generation of ROS, which in turn activates the NF-B signaling axis, amplifying downstream oncogenic pathways and contributing to tumor development and immune evasion [58]

I., & Korkina, L

Furthermore, as described, another family member of the RCAN family is involved in DS cardiac alterations, specifically with cardiac contraction (Figure 2)